Services

1. Standardized and validated serum-free human and rat hepatocyte cultures. In addition, on request
  • Serum-free mouse hepatocyte cultures
  • Serum-free HepG2 hepatoma cell cultures
  • Culture of additional cell lines
2. Analyses of acute toxicity: Impact of xenobiotics on vitality and functionality of hepatocyte cultures.

3. Metabolism of drugs / biotransformation: Induction of various cytochrome P450 proteins and monitoring changes in expression of these proteins
  • Analysis of protein expression (Western blots)
  • HPLC-based analyses of enzymatic activities
  • Two-dimensional protein electrophoresis and mass spectrometry
  • RNA expression arrays
The quality of our cell cultures is subjected to a tight control. Hepatocellular vitality and functionality is monitored daily. These assays are conducted by an independent, ISO 9001:2000 certified laboratory.

Partner

HELIOS-Kliniken Schwerin
  • Institut für Laboratoriumsmedizin, Prof. Dr. H. G. Lestin
  • Klinik für Chirurgie Abt. für Allgemein und Visceralchirurgie, Dr. med. Klaus Dommisch
  • Institut für Pathologie, Dr. med. Raoul Hinze
University of Pittsburgh, Pittsburgh, USA
  • Department of Pathology, George K. Michalopoulos, MD, PhD
  • Department of Pathology, Stephen C. Strom, PhD
  • Center for Biological Imaging, Donna Beer Stolz, PhD
Universität Leipzig
  • Zentrum für Toxikologie, Prof. Dr. Jan Hengstler
Universität Rostock
  • Institut für Immunologie, Dr. Dirk Koczan
  • Proteom Zentrum Rostock, Prof. Dr. Michael O. Glocker